研究成果｜Publications

■ 学術論文｜Articles

• Tomita K, Yamanaka K, Nguyen TV, Kim J, Pham LT, Kobayashi T, Gouraud SS, Waki H.
  Potential role of signal transducer and activator of transcription 3 in the amygdala in mitigating stress-induced high blood pressure via exercise in rats.
  Acta Physiol (Oxf). 2025 Feb;241(2):e14274. doi: 10.1111/apha.14274. PMID: 39801202.

• Yamanaka K, Suzuki M, Pham LT, Tomita K, Van Nguyen T, Takagishi M, Tsukioka K, Gouraud S, Waki H.
  Involvement of D1 dopamine receptor in the nucleus of the solitary tract of rats in stress-induced hypertension and exercise.
  J Hypertens. 2024 Jul 5. PMID: 38973449.

• Nguyen TV, Yamanaka K, Tomita K, Zubcevic J, Gouraud SSS, Waki H.
  Impact of exercise on brain-bone marrow interactions in chronic stress: potential mechanisms preventing stress-induced hypertension.
  Physiol Genomics. 2023 Mar 20.
  doi: 10.1152/physiolgenomics.00168.2022. Epub ahead of print. PMID: 36939204.

• Ezure S, Ichihara H, Yamanaka K, and Waki H.
  Functional connectivity in the central nucleus of the amygdala, paraventricular hypothalamus, and the nucleus tractus solitarii circuits during high-intensity treadmill exercise in rats
  Journal of Physical Fitness and Sports Medicine, 2023. May 25, Vol.12(3),

• 山中航, 香月翔太, 河村剛光, 和氣秀文
  仮想現実サイクリング運動時の競争他者が心血管応答および運動パフォーマンスに及ぼす影響〜自律神経生理尺度を活用したメンタルバイオマーカーの開発
  The Effects of Competitors on the Cardiovascular Response and Performance during Virtual Reality Cycling Exercise – the Development of a Mental Biomarker Utilizing Physiological Parameters
  デサントスポーツ科学, 第44号, 2023, 61-69.

• Tsukioka K, Yamanaka K, Waki H.
  Implication of the central nucleus of the amygdala in cardiovascular regulation and limiting maximum exercise performance during high-intensity exercise in rats
  Neuroscience. 2022 Jun 8;S0306-4522(22)00290-1. doi: 10.1016/j.neuroscience.2022.06.005.

• Yamanaka K and Waki H.
  Conditional regulation of blood pressure in response to emotional stimuli by the central nucleus of the amygdala in rats
  Front. Physiol., 01 June 2022

• 和氣秀文, 山中航
  「第2章 運動と健康 2.心身の健康を支える体力と運動」
  （編）曽根博仁『すべての診療科で役立つ身体運動学と運動療法』
  2022/3/22

• Pham LT, Yamanaka K, Miyamoto Y, Waki H, Gouraud S.
  Estradiol-dependent gene expression profile in the amygdala of young ovariectomized spontaneously hypertensive rats
  Physiol Genomics. 2022 Mar 1;54(3):99-114. doi: 10.1152/physiolgenomics.00082.2021. Epub 2022 Jan 31.
  PubMed

• 和気秀文, 山中航
  宇宙医学における自律神経性心血管調節に関する研究
  Effects of space flight on autonomic cardiovascular regulation
  Precision Medicine, 2021年8月(宇宙航空医学の現在と展望)
  北隆館

• 香月翔太, 河村剛光, 和気秀文, 山中航
  VRサイクリング運動時の競争他者によって誘発される情動変化が運動パフォーマンスおよび自律神経応答に及ぼす影響
  映像情報メディア学会技術報告 ITE Technical Report Vol.44, No.31, HI2020-74(Nov.2020)
  技報オンラインシステム

• Yamanaka K, Waki H.
  Regulation of blood pressure by the central nucleus of the amygdala in dynamically changing appetitive and aversive classical conditioning tasks in rats.
  Research Square (Preprint), 24 Nov 2020, PPR: PPR244065 DOI:10.21203/rs.3.rs-109253/v2
  Preprint Ver.2
  Ver.1

• 山中航, 和気秀文
  運動時の動機づけと情動－線条体と扁桃体に着目して－
  体育の科学 70巻11月号（特集　運動技能を支える神経メカニズムの新知見）, 2020年11月
  杏林書院

• Fukuo M, Kamagata K, Kuramochi M, Andica C, Tomita H, Waki H, Sugano H, Tange Y, Mitsuhashi T, Uchida W, Takenaka Y, Hagiwara A, Harada M, Goto M, Hori M, Aoki S, Naito H.
  Regional brain gray matter volume in world-class artistic gymnasts
  J Physiol Sci. 2020 Sep 18;70(1):43. doi: 10.1186/s12576-020-00767-w.
  Pubmed | Journal

• Kim J†, Yamanaka K†, Tsukioka K, Waki H. (†Equal contribution)
  Potential Role of the Amygdala and Posterior Claustrum in Exercise Intensity-dependent Cardiovascular Regulation in Rats.
  Neuroscience. 2020 Feb 26. pii: S0306-4522(20)30110-X.
  PubMed | Journal

• Naito H, Shibata N, Takazawa Y, Waki H
  Achievements and prospects of Juntendo University Institute of Health and Sports Science & Medicine.
  Juntendo Medical Journal, 66 (Suppl.1): 108-113, 2020

• Andica C, Tomita H, Kamagata K, Uchida W, Murata S, Hagiwara A, Fukuo M, Waki H, Sugano H, Tange Y, Mitsuhashi T, Harada M, Naito H, HoriM, Aoki S
  White matter myelin changes related to long-term intensive training in Japanese world-class gymnasts.
  Juntendo Medical Journal, 66(Suppl.1): 21-28, 2020

• 和気秀文, Gouraud Sabine.
  12．運動トレーニングによる高血圧改善の機序――中枢性機序を中心に, 連載【健康寿命延伸に寄与する体力医学】
  医学のあゆみ, 270(2), 2019

• Tsukioka K, Yamanaka K, Waki H.
  Effects of bilateral lesions in the central amygdala on spontaneous baroreceptor reflex in conscious rats.
  JPFSM, 2019 Jan 25. Vol.8(1)

• Yamanaka K, Kurosaka W, Kawata Y, Waki H.
  Behavioral tracking of possibility for exercise in rats
  Juntendo Medical Journal, 64(Suppl 1): 80, 2018 (Proceedings)

• Kim J, Yamanaka K, Tsukioka K, Takagishi M, Gouraud S, Waki H.
  Involvement of the caudal part of insular cortex and central nucleus of the amygdala in cardiovascular regulation during exhausting exercise.
  Juntendo Medical Journal, 64(Suppl 1): 81-82, 2018 (Proceedings)

• Onishi M, Yamanaka K, Miyamoto Y, Waki H, Gouraud SS.
  Trpv4 involvement in the gender differences in blood pressure regulation in spontaneously hypertensive rats.
  Physiol Genomics, 2018 Apr 1;50(4):272-286. Jan 26. doi: 10.1152/physiolgenomics.00096.2017. [Epub ahead of print] PMID: 29373075

• Nakao T, Kohsaka A, Otsuka T, Thein ZL, Le HT, Waki H, Gouraud SS, Ihara H, Nakanishi M, Sato F, Muragaki Y, Maeda M.
  Impact of heart-specific disruption of the circadian clock on systemic glucose metabolism in mice.
  Chronobiol Int. 2017 Dec 22:1-12. doi: 10.1080/07420528.2017.1415922.

• Suzuki M, Shindo D, Suzuki R, Shirataki Y, Waki H.
  Combined long-term caffeine intake and exercise inhibits the development of diabetic nephropathy in OLETF rats.
  J Appl Physiol (1985). 2017 May 1;122(5):1321-1328. doi: 10.1152/japplphysiol.00278.2016.

• Yamanaka K, Hori Y, Minamimoto T, Yamada H, Matsumoto N, Enomoto K, Aosaki T, Graybiel AM, Kimura M.
  Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events.
  J Neural Transm (Vienna). 2018 Mar;125(3):501-513.
  Mar 21. doi: 10.1007/s00702-017-1713-z. [Epub ahead of print] Review. PMID: 28324169

• Yamanaka K, Gouraud SS, Takagishi M, Kohsaka A, Maeda M, Waki H.
  Evidence for a histaminergic input from the ventral tuberomamillary nucleus to the solitary tract nucleus involved in arterial pressure regulation.
  Physiol Rep. 2017 Mar;5(5). pii: e13095. doi: 10.14814/phy2.13095. PMID: 28292881

• Yamanaka K, Takagishi M, Kim J, Gouraud SS, Waki H.
  Bidirectional cardiovascular responses evoked by microstimulation of the amygdala in rats.
  J Physiol Sci., Vol.68(3): 233-242, 2017 Jan 23.
  doi: 10.1007/s12576-017-0523-2. [Epub ahead of print] PMID: 28111704

• Marvar PJ, Hendy EB, Cruise TD, Walas D, DeCicco D, Vadigepalli R, Schwaber JS, Waki H, Murphy D, Paton JF.
  Systemic leukotriene B4 receptor antagonism lowers arterial blood pressure and improves autonomic function in the spontaneously hypertensive rat.
  J Physiol., 594(20): 5975-5989, 2016

• Waki H, Yamanaka K, Takagishi M, Gouraud S.
  The brain histaminergic system in regulating the cardiovascular system: implications for brain mechanisms underlying exercise-induced cardiovascular responses.
  Juntendo Medical Journal, 62 (Suppl 1): 81-86, 2016

• Gouraud SS, Takagishi M, Kohsaka A, Maeda M, Waki H.
  Altered neurotrophic factors expression profiles in the nucleus of the solitary tract of spontaneously hypertensive rats.
  Acta Physiol. (Oxf), doi: 10.1111/apha.12618, 2015

• Sakata S, Hanaoka T, Ishizawa R, Iwami K, Takada Y, Imagita H, Minematsu A, Waki H, Nakatani A.
  Poor wheel-running exercise can decrease blood pressure through hormonal control and increase endurance exercise capacity in middle-aged normal rats.
  Journal of Biosciences and Medicines, 3: 10-24, 2015

• Kohsaka A, Das P, Hashimoto I, Nakao T, Deguchi Y, Gouraud SS, Waki H, Muragaki Y, Maeda M.
  The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice.
  PLoS One, 9(11):e112811. doi: 10.1371/journal.pone.0112811. 2014

• Sakata S, Nakatani A, Waki H.
  Possible mechanisms underlying wheel-running-induced hypotensive effects.
  J Phys Fitness Sports Med, 3(4): 429-433, 2014

• Waki H (corresponding author), Takagishi M, Gouraud SS.
  Central mechanisms underlying anti-hypertensive effects of exercise training.
  J Phys Fitness Sports Med, 3(3): 317-325, 2014

• Katsuda S, Yamasaki M, Waki H, Miyake M, O-ishi H, Katahira K, Nagayama T, Miyamoto Y, Hasegawa M, Wago H, Okouchi T, Shimizu T.
  Spaceflight affects postnatal development of the aortic wall in rats.
  Biomed Res Int, 2014:490428. doi: 10.1155/2014/490428, 2014

• Sueta D, Koibuchi N, Hasegawa Y, Toyama K, Uekawa K, Katayama T, Ma MJ, Nakagawa T, Waki H, Masanobu Maeda M, Ogawa H.
  Blood pressure variability, impaired autonomic function and vascular senescence in aged spontaneously hypertensive rats are ameliorated by angiotensin blockade.
  Atherosclerosis, 236(1):101-107, 2014

• Takagishi M, Gouraud SS, Bhuiyan ME, Kohsaka A, Maeda M, Waki H (corresponding author).
  Activation of histamine H1 receptors in the nucleus tractus solitarii attenuates cardiac baroreceptor reflex function in rats.
  Acta Physiol (Oxf). 211: 73-81, 2014

• Waki H (corresponding author), Gouraud S.
  Brain inflammation in neurogenic hypertension.
  World J Hypertens 4: 1-6, 2014.

■ 著書｜Books

• 和氣秀文, 山中航 運動が（個別の人の）心身の健康へ及ぼす影響 編)曽根博仁『すべての診療科で役立つ身体運動学と運動療法』
  羊土社

• 和気秀文：7 健康・スポーツ生理学(4) 呼吸・循環,「健康・スポーツ科学研究(‘21)」関根紀子編,放送大学教育振興会,pp107-127, 2021

• 和気秀文：10 健康・スポーツの科学的理解(2) 呼吸・循環系と運動,「健康・スポーツ科学研究(‘21)」関根紀子編,放送大学教育振興会, pp162-181, 2021

• 和気秀文他（監修）:「病気がみえるvol.11運動器・整形外科（第1版）」運動器の生理.　株式会社メディックメディア, 東京, pp8-38, 2017

• 和気秀文: 「ニュー運動生理学（I）（II）」第１１章　運動と循環－４,心血管の中枢性調節. 宮村実晴編集, 真興交易株式会社医書出版部, 東京, 2014

• 和気秀文: 「血圧」特集　炎症・免疫と高血圧、中枢炎症と高血圧. 血圧 Vol.20, No11, 先端医学社, 東京, 1074-1078, 2013

• 和気秀文:「身体運動と呼吸・循環機能」II循環機能－4. 孤束核と循環調節との関係. 宮村実晴編集, 真興交易株式会社医書出版部, 東京, pp218-227, 2012

• 向阪彰, 和気秀文, 前田正信:「心臓・循環の生理学」第４章　心拍の開始とその神経性調節（翻訳）. J.R. Levick著,「An Introduction to Cardiovascular Physiology, 5th ed」, メディカル・サイエンス・インターナショナル, 東京,　pp49-63, 2011

• 和気秀文, 小宮秀明, 淵本隆文, 鈴木政登:　｢運動処方の指針（原書第８版）｣　第４章　健康関連体力テストおよびその解釈（翻訳）.　「ACSM’s Guidelines for Exercise Testing and Prescription; 8th Edition」, 南江堂, 東京,　pp60-104, 2011

• 和気秀文, 前田正信: 「エッセンシャル神経科学」第22章 自律神経系（翻訳）.　Allan Siegel & Hreday N. Sapru 著,「Essential Neuroscience」, 丸善株式会社, 東京,　pp373-398, 2008

• Paton JFR, Waki H, Raizada M and Kasparov S: Genes Regulating Cardiovascular Function As Revealed Using Viral Vectors. In Neural Mechanisms of Cardiovascular Regulation Eds. Dun N.J., Machado, B.M. & Pilowsky, P.M., Ch18, Kluwer Academic Publishers, Boston, Dordrecht, London, pp399-408, 2004

• Shimizu T, Yamasaki M, Waki H, Katsuda S, Oishi H, Katahira K, Nagayama T, Miyake M and Miyamoto Y: Development of the aortic baroreflex in microgravity. In The Neurolab, Spacelab Mission: Neuroscience Research in Space. Eds. Jay C. Buckey, Jr. & Jerry L. Homick, NASA SP 2003 535, pp151-159, 2003

■ 特許 | Patent

• 特願2018-128559 特開2020-005548 特許7144803 2022年10月04日　動物飼育ケージ
  　特許情報プラットフォーム

■ GEO repository

[NCBI tracking system #18509369] Accession Title Release date Status Supplementary files

GSE100189 Gender differences of gene expression profiles in the Nucleus of Solitarii Tract Jul 15, 2017 approved None
GSM2674331 SHR NTS Male Jul 15, 2017 approved TXT
GSM2674332 SHR NTS Female Jul 15, 2017 approved TXT
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE100189

GSE100198 Gender differences of gene expression profiles in the Hypothalamus Jul 15, 2017 approved None
GSM2674515 SHR HYPO Male Jul 15, 2017 approved TXT
GSM2674516 SHR HYPO Female Jul 15, 2017 approved TXT
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE100198